Clinical Significance of Plasma Leptin and Its Receptors mRNA Expression in Craniopharyngiomas: A Prospective Study
نویسندگان
چکیده
Craniopharyngioma (CP) is a benign tumor with high rate of obesity and frequent recurrence. Moreover, the role leptin/leptin receptors axis in prognosis CP still unknown. Plasma leptin concentration mRNA expression were assessed patients CP. association between axis, weight-related outcomes, progression-free survival (PFS) explored patients. Leptin overexpressed tissue compared to normal brain (p < 0.05); healthy controls, was elevated or without matched age, sex, body mass index (BMI) 0.05). The plasma level an independent risk predictor for significant weight gain (adjusted odds ratio (aOR) = 2.29, p 0.030) new-onset (aOR 6.64, 0.016). High hazard (aHR) 3.74, 0.011) receptor (LEPR) (aHR 3.12, 0.045) factors poor PFS Inappropriately relative BMI its failure inhibit further indicate existence resistance LEPR predictors may be potential therapeutic target
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ژورنال
عنوان ژورنال: Biomolecules
سال: 2023
ISSN: ['2218-273X']
DOI: https://doi.org/10.3390/biom13071078